Meropenem and ciprofloxacin combination regimens against isogenic Pseudomonas aeruginosa strains with different resistance mechanisms in a dynamic hollow fibre model
Effect of different resistance mechanisms on bacterial killing and resistance emergence of Pseudomonas aeruginosa in response to meropenem dosing regimens in a hollow fibre model
Synergistic killing of Acinetobacter baumannii (AB) elicited by simultaneous inactivation of three or all four penicillin-binding proteins (PBPs) among PBP1a, 1b, 2 and 3
Inhaled aztreonam and tobramycin dosing regimens against hypermutable cystic fibrosis Pseudomonas aeruginosa isolates in a dynamic in vitro biofilm model
Time-course analysis of the metabolomic footprint of an MDR hypermutable Pseudomonas aeruginosa clinical isolate challenged with ceftolozane/tazobactam in a hollow-fibre infection model
Ceftolozane/tazobactam in combination with tobramycin against the planktonic and biofilm states of hypermutable Pseudomonas aeruginosa isolates from paediatric patients with cystic fibrosis
Simultaneously inactivating three or all four penicillin-binding proteins (PBPs) among PBP1a, 1b, 2 and 3 synergistically kills Acinetobacter baumannii (AB)
Optimising combination dosage regimens of piperacillin/tazobactam plus tobramycin against a clinical Pseudomonas aeruginosa isolate in a dynamic in vitro infection model
Synergistic meropenem tobramycin combination dosage regimens against clinical hypermutable Pseudomonas aeruginosa at simulated epithelial lining fluid concentrations in a dynamic biofilm model
Evaluation of synergistic meropenem-ciprofloxacin combination dosage regimens for critically ill patients with altered pharmacokinetics via mechanism-based modelling and the dynamic hollow fibre infection model
Impact of hypermutation on the time-course of resistance emergence of Pseudomonas aeruginosa exposed to diverse clinically important antibiotics in monotherapy and combination
Evaluation of meropenem plus tobramycin combination regimens to combat carbapenem nonsusceptible Pseudomonas aeruginosa for critically-ill patients with augmented renal clearance via the hollow-fibre infection model and mechanism-based modelling
Pharmacodynamics of ceftazidime plus tobramycin combination dosage regimens against hypermutable Pseudomonas aeruginosa isolates at simulated epithelial lining fluid concentrations in a dynamic in-vitro model
Optimizing a meropenem plus tobramycin combination dosage regimen against hypermutable and non-hypermutable Pseudomonas aeruginosa via mechanism-based modelling and the hollow-fibre infection model
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