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From the archive: ECCMID and more before 2010
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11 July 2021 - 1280
Bactericidal activity of ethionamide alone and boosted by BVL-GSK098 in an acute murine model of tuberculosis
Thomas Maitre, T. Maitre (1), S. Lociuro (2), M. Pieren (2), A. Chauffour (1), L. Fournier Le Ray (1), A. Aubry (1, 3), N. Willand (4), A. Baulard (5), M. Remuiñán (6), J. Rullás (6), G. Dale (2), M. Gitzinger (2), N. Veziris (1, 3, 7)
11 July 2021 - 854
How to turn an old drug into a potent, rapidly bactericidal and safer drug: clinical candidate BVL-GSK098 overcomes resistance to and potentiates the activity of ethionamide by boosting ethionamide bioactivation in Mycobacterium tuberculosis
Alain Baulard, A. Baulard (1), N. Willand (2), R. Frita (3), M. Flipo (2), B. Deprez (2), M. Remuiñán (4), A. Mendoza (4), M.J. Rebollo (4), E. Pérez-Herrán (4), D. Barros (4), A. Trauner (5), S. Gagneux (6), V. Trebosc (5), C. Kemmer (5), M. Bourotte (3), M. Gitzinger (5), G. Dale (5), M. Pieren (5), S. Lociuro (5)
10 July 2021 - 2550
Inhibition of AgrA-mediated virulence factor expression in MRSA: a viable, non-lethal, treatment option
Andrej Trauner, A. Trauner (1), J. Schill (1), A. Michelotti (2), A. Ballee (2), S. Söderholm (3), C. Kemmer (1), B. Schellhorn (1), V. Lucchini (1), M. Pieren (1), V. Trebosc (1), O. Defert (2), M. Bourotte (2), M. Gitzinger (1), D. Bumann (3), G. Dale (1), S. Lociuro (1)
09 July 2021 - 863
Therapeutic efficacy of ethionamide boosted with BVL-GSK098 in an acute murine model of tuberculosis
Modesto Remuiñán, M. Remuiñán (1), J. Rullás (1), L. Guijarro (1), D. Barros (1), N. Willand (2), M. Flipo (2), B. Deprez (2), A. Baulard (3), R. Frita (4), M. Gitzinger (5), G. Dale (5), M. Pieren (5), S. Lociuro (5)
23 April 2018 - P1661
Murepavadin activity tested against contemporary (2016-2017) clinical isolates of extensively drug-resistant (XDR) Pseudomonas aeruginosa
David Greig, H. Sader, R. Flamm, G. Dale, P. Rhomberg, M. Castanheira
23 April 2018 - P1668
Outer membrane protein targeting antibiotics (OMPTAs): investigation of the in vitro time-kill kinetics and rate of resistance development by serial passage
Sachin Bhagwat, F. Bernardini, C. Verbree, S. Stiegeler, P. Chiquet, G. Dale
23 April 2018 - P1667
Investigation of the in vitro time-kill kinetics and the rate of resistance development by spontaneous mutations and serial passage of murepavadin and standard-of-care antibiotics towards P. aeruginosa
Karin Meinike Jørgensen, F. Bernardini, P. Chiquet, C. Verbree, S. Stiegeler, G. Dale
23 April 2018 - P1662
Antimicrobial activity of murepavadin tested against clinical isolates of Pseudomonas aeruginosa collected in Europe, the United States and China
Helio S. Sader, H. Sader, G. Dale, L. Duncan, P. Rhomberg, R. Flamm
23 April 2018 - P1665
Outer membrane protein targeting antibiotics (OMPTAs): in vivo characterization of a novel class of compounds with respect to pharmacokinetics, efficacy and renal toxicity
Glenn Dale, G. Dale, A. Luther, J. Teague, D. Markovic, F. Bernardini, D. Obrecht
23 April 2018 - P1666
Outer mebrane protein targeting antibiotics (OMPTAs): a novel class with potent in vitro and in vivo activity against E. coli-harbouring mcr-1 and/or mcr-3 genes
Glenn Dale, G. Dale, J. Teague, C. Vingsbo Lundberg, A. Luther, F. Bernardini, D. Obrecht
21 April 2018 - O0246
Outer membrane protein targeting antibiotics (OMPTAs): a novel class with potent activity against Gram-negative organisms including XDR and colistin-resistant isolates
Anatol Luther, A. Luther, F. Bernardini, G. Dale, C. Verbree, S. Stiegeler, P. Chiquet, D. Obrecht
11 April 2016 - P1307
Metabolism and excretion of the novel macrocycle antibiotic POL7080
Glenn E. Dale, O. Kuhlmann, C. Brealey, S. Simon, M. Ullah, M. Pantze, A. Wach, G. Dale
11 April 2016 - P1308
Pharmacokinetics and safety of POL7080 in subjects with impaired renal function
Glenn E. Dale, A. Halabi, M. Peterson-Sylla, K. Sommerville, A. Wach, K. Dembowsky, M. Rangaraju, G. Dale
11 April 2016 - P1309
Pharmacokinetics of POL7080 co-administered with standard of care (SoC) in patients with ventilator-associated pneumonia (VAP) due to suspected or documented Pseudomonas aeruginosa infection
Glenn E. Dale, A. Armaganidis, F. Frantzeskaki, C. Diakaki, S. Zakynthinos, E. Ischaki, K. Mandragos, C. Katsenos, M. Paraschos, M. Patrani, E. Giamarellos-Bourboulis, N. Antonakos, G. Damoraki, M. de la Torre-Prados, K. Sommerville, M. Rangaraju, K. Dembowsky, L. Hooftman, A. Wach, G. Dale, A. Torres
10 April 2016 - O288
Interim analysis of the efficacy of POL7080 co-administered with standard-of-care (SoC) in a phase II study in patients with ventilator-associated pneumonia (VAP) due to suspected or documented Pseudomonas aeruginosa infection
Apostolos Armaganidis, Armaganidis Apostolos, A. Armaganidis, F. Frantzeskaki, C. Diakaki, . Apostolopoulou, S. Zakynthinos, E. Ischaki, K. Mandragos, C. Katsenos, M. Paraschos, M. Patrani, E. Giamarellos-Bourboulis, A. Pistiki, T. Tsaganos, P. Ramirez Galleymore, M. de la Torre-Prados, M. Rangaraju, K. Dembowsky, L. Hooftman, G. Dale, A. Torres
09 April 2016 - P0345
Activity of novel antibiotic POL7080 against clinical isolates from a surveillance programme in CN (2012 and 2013)
Glenn E. Dale, G. Dale, P. Rhomberg, I. Najera, C. Zampaloni, R. Flamm
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