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ESCMID Global 2024
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From the archive: ECCMID and more before 2010
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18 September 2024
Old target/optimised chemistry: BV100 for CRAB
Glenn Dale
17 September 2024 - EA024
Impact of combination with BV100 on the antibacterial effect of polymyxin B against Acinetobacter baumannii
Pippa Griffin, Marie Attwood, Alan Noel, Birgit Schellhorn, Vincent Trebosc, Glenn Dale, Alasdair MacGowan
30 April 2024 - O1337
Minimal inhibitory concentration of ethionamide alone and in combination with alpibectir on drug-sensitive and drug-resistant clinical isolates of Mycobacterium tuberculosis
Line Hofmann, Praha Rupasinghe, Leen Rigouts, Bouke De Jong, Karine Soetaert, Vanessa Mathys, Nicolas Willand, Modesto Remuiñán, Marc Gitzinger, Glenn Dale, Alain Baulard, Michel Pieren
28 April 2024 - P2294
In vitro activity of rifabutin combined with polymyxin B in Acinetobacter baumannii
Vincent Trebosc, Birgit Schellhorn, Julian Schill, Marc Gitzinger, Sergio Lociuro, Glenn Dale, Christian Kemmer
28 April 2024 - P2444
Pharmacokinetics of ethionamide and ethionamide sulfoxide in patients established on treatment for tuberculosis
Michel Pieren, Pierre Delique, Lisa Husband, Marc Gitzinger, Caryn Upton, Jeantelle Du Preez, Glenn Dale
28 April 2024 - P2449
Pharmacokinetic and pharmacodynamic properties of polymyxin B in Acinetobacter baumannii murine infection models
Sanne Van Den Berg, Michel Pieren, Sebastiaan Sassen, Marian Ten Kate, Glenn Dale, Anouk Muller,
28 April 2024 - P2429
Pharmacokinetics and safety of BV100 in subjects with mild and moderate hepatic impairment
Pierre Delique, Lisa Husband, Geza Lakner, Koppany Kis, Sebastian Zimmermann, Jon Moss, Christian Kemmer, Glenn Dale,
28 April 2024 - P2295
In vivo efficacy of BV100 in combination with polymyxin B (POL) in neutropenic murine thigh infection models of Acinetobacter baumannii
Michel Pieren, Sanne Van Den Berg, Mark E. Pulse, William Weiss, Jessica S.C. Boonman, Anouk Edwina Muller, Francoise Jung, Glenn Dale
28 April 2024 - P2431
BV100 displays potent efficacy against Acinetobacter baumannii in neutropenic murine thigh and lung infection models
Michel Pieren, Anouk Edwina Muller, Mark E. Pulse, William Weiss, Willem A. M. De Jong, Van Den Berg Sanne, Francoise Jung, Glenn Dale
17 April 2023 - P2130
In vitro activity of rifabutin combined with low dose polymyxin B in Acinetobacter baumannii
Vincent Trebosc, Birgit Schellhorn, Julian Schill, Marc Gitzinger, Sergio Lociuro, Christian Kemmer, Glenn Dale
17 April 2023 - P2189
Population pharmacokinetic meta-analysis of BV100 in healthy subjects and renally impaired subjects
Jon Moss, Michael Watts, Joachim Grevel, Sergio Lociuro, Marc Gitzinger, Christian Kemmer, Glenn Dale
17 April 2023 - P2279
Pharmacokinetics of BV100 in subjects with renal impairment
Christian Kemmer, Geza Lakner, Perte Kovacs, Ana Abáigar Gutiérrez-Solana, Martin Hirsch, Lisa Husband, Sergio Lociuro, Marc Gitzinger, Glenn Dale
17 April 2023 - P2188
Revisiting ethionamide in vivo activity through its metabolite exposure
Thomas Maitre, Glenn Dale, Zainab Edoo, Mohammad Al-Shaer, Anne-Grete Märtson, Caryn Upton, Céline Mory, Najoua El Helali, Aurélie Chauffour, Laure Fournier Le Ray, Alexandre Godmer, Alexandra Aubry, Aurore Dreneau, Nicolas Willand, Alain Baulard, Marc Gitzinger, Sergio Lociuro, Michel Pieren, Nicolas Veziris
23 April 2022 - P1272
In vitro activity of BV200 anti-virulent small molecules against a large and geographically diverse panel of Staphylococcus aureus isolates from skin and lung infections
Vincent Trebosc, Julian Schill, Birgit Schellhorn, Alessia Michelotti, Marc Gitzinger, Michel Pieren, Marilyne Bourotte, Glenn Dale, Olivier Defert, Sergio Lociuro
23 April 2022 - P1275
Structure-activity relationships of rifabutin analogues for potent activity against Acinetobacter baumannii
Vincent Trebosc, Mathieu Maingot, Birgit Shellhorn, Kevin Antraygues, Hugo Scherer, Marc Gitzinger, Christian Kemmer, Marilyne Bourotte, Olivier Defert, Glenn Dale, Sergio Lociuro, Nicolas Willand
23 April 2022 - P1260
Label-free quantitative proteomic reveals the broad anti-toxin activity of BV200 anti-virulent agents against Staphylococcus aureus.
Vincent Trebosc, Minia Antelo-Varela, Julian Schill, Alessia Michelotti, Marc Gitzinger, Glenn Dale, Marilyne Bourotte, Olivier Defert, Michel Pieren, Andrej Trauner, Alexander Schmidt, Dirk Bumann, Sergio Lociuro
23 April 2018 - P1665
Outer membrane protein targeting antibiotics (OMPTAs): in vivo characterization of a novel class of compounds with respect to pharmacokinetics, efficacy and renal toxicity
Glenn Dale, G. Dale, A. Luther, J. Teague, D. Markovic, F. Bernardini, D. Obrecht
23 April 2018 - P1666
Outer mebrane protein targeting antibiotics (OMPTAs): a novel class with potent in vitro and in vivo activity against E. coli-harbouring mcr-1 and/or mcr-3 genes
Glenn Dale, G. Dale, J. Teague, C. Vingsbo Lundberg, A. Luther, F. Bernardini, D. Obrecht
25 April 2017 - OS1020
Population pharmacokinetics of Murepavadin (POL7080) and Monte Carlo simulations to develop clinical dosing regimens, including the renally impaired
Johan W. Mouton, Brenda De Winter, Anouk Muller, Glenn Dale, Achim Wach, Johan Mouton
25 April 2017 - OS1019
Pharmacokinetics and pharmacodynamics of murepavadin (POL7080) in neutropenic lung infection models
Glenn E. Dale, Johan Mouton, M.j Melchers, Joanne Teague, Pia Thommes, Peter Warn, Jon Hansen, Carina Vingsbo Lundberg, Francesca Bernardini, Daniel Obrecht, Glenn Dale
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