Thomas Lodise, Anouk Edwina Muller, , Kushal Umarkar, Swapna Takalkar, Rajesh Chavan, Hariharan Periasamy, Sachin Bhagwat, Mahesh Patel
Poster Session
ESCMID Global 2024
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From the archive: ECCMID and more before 2010
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28 April 2024
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P2461
In vivo efficacy of humanized pulmonary exposures of WCK 5222 (cefepime/zidebactam) in neutropenic murine lung infection caused by carbapenemase-producing Klebsiella pneumoniae (KP) and Acinetobacter baumannii (AB) with WCK 5222
28 April 2024
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P2297
In vitro activity of cefepime/zidebactam (WCK 5222) against a panel of MDR/XDR Pseudomonas aeruginosa isolates from India enriched with resistance to novel β-lactam/ β-lactamase inhibitor combinations
16 April 2019
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O1063
WCK-771 (INN: levonadifloxacin): pharmacodynamic index (PDI) and PD target (PDT) determination studies involving methicillin /quinolone-resistant Staphylococcus aureus (MRSA/QRSA) employing neutropenic mouse lung infection model
Sachin Bhagwat, Pavan Tayde, Kushal Umarkar, Amol Kulkarni, Jaykumar Satav, Swapna Takalkar, Hariharan Periasamy, Rajesh Chavan, Vineet Zope, Mahesh Patel
Abstract Publication
16 April 2019
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P2769
Selection of EUCAST disk potency for WCK 4282 (cefepime-tazobactam, FEP-TAZ) susceptibility testing against Enterobacterales and Pseudomonas aeruginosa
Sachin Bhagwat, Jiji Joseph, Erika Matuschek, Raju Thombre, Hemant Khande, Suyog Vaidya, Snehal Palwe, Hariharan Periasamy, Helio S. Sader, Jane Ambler, Mahesh Patel, Gunnar Kahlmeter
Abstract Publication
16 April 2019
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P2770
Selection of EUCAST disk potency for WCK 5222 (cefepime-zidebactam, FEP-ZID) susceptibility testing against Enterobacterales, Pseudomonas aeruginosa and Acinetobacter baumannii
Sachin Bhagwat, Ajabrao Kute, Erika Matuschek, Melroy Tellis, Hemant Khande, Suyog Vaidya, Snehal Palwe, Hariharan Periasamy, Helio S. Sader, Jane Ambler, Mahesh Patel, Gunnar Kahlmeter
Abstract Publication
15 April 2019
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P1954
Population pharmacokinetics of zidebactam (WCK5107), a novel beta-lactam enhancer antibiotic, in individuals with various renal function
15 April 2019
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P1970
Population pharmacokinetics and dose adjustment of cefepime/tazobactam high dose (WCK4282) in patients with intermittent haemodialysis
15 April 2019
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P1941
Pharmacokinetic-pharmacodynamic (PK-PD) target attainment analyses to support WCK-771 (INN: levonadifloxacin) clinical dose selection
25 April 2017
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EP0943
Population pharmacokinetics, Monte Carlo simulations and dosing recommendations of cefepime using 2h infusion, including renal impairment
25 April 2017
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OS1017
WCK 4873 (Nafithromycin): PK/PD analysis for H. influenzae (HI) through murine lung infection model
25 April 2017
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OS1016
WCK 4282 [high-dose Cefepime (FEP)-Tazobactam (TAZ)]: In-vivo PK/PD studies identifying TAZ threshold concentrations (CT) against AmpC P. aeruginosa (PA)
24 April 2017
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P1350
WCK 4873 (Nafithromycin): Impact of hyper ermB induction in S. pneumoniae and S. aureus on the activity of ketolides
24 April 2017
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P1179
Population pharmacokinetics, Monte Carlo simulations and dose adjustment of tazobactam including in the renally impaired
24 April 2017
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P1302
A novel beta-lactam enhancer Gram-negative antibiotic, zidebactam (ZID) - phenotypic and genotypic characteristics of ZID-selected mutants of Enterobacteriaceae - expressing Class C, KPC and NDM
24 April 2017
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P1300
Zidebactam (WCK 5107) and WCK 5153: Bicyclo-acyl hydrazide penicillin-binding-protein (PBP) inhibitors showing potent beta-lactam enhancer activity against multidrug-resistant (MDR) metallo-beta-lactamase (MBL)-producing Klebsiella pneumoniae
24 April 2017
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OS0560
Unraveling the cefepime-zidebactam synergy basis against metallo-beta-lactamase (MBL)-producing Pseudomonas aeruginosa through penicillin-binding protein (PBP) binding dynamics
11 April 2016
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P1259
WCK 4282 (high-dose cefepime-tazobactam) – assessment of synergy through time-kill curve and MIC determination against Pseudomonas aeruginosa producing OXA and VEB beta-lactamases
11 April 2016
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P1266
WCK 4282 (high-dose cefepime-tazobactam) – time-kill studies correlate with in vivo efficacy studies against AmpC-producing Pseudomonas aeruginosa
Mahesh Patel, Comella Connie, Patel Mahesh, K. Umarkar, J. Satav, A. Uday, A. Kulkarni, H. Khande, S. Palwe, S. Takalkar, S. Bhagwat, M. Patel
Session: Cefepime-tazobactam
Poster Presentation
09 April 2016
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EV0631
WCK 4282 (high-dose cefepime-tazobactam) extends coverage to carbapenem-resistant Klebsiella harbouring multiple ESBLs, OXA 48/181 in conjunction with impermeability
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