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From the archive: ECCMID and more before 2010
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01 April 2012 - P1419
GSK2251052, a novel, leucyl tRNA synthetase inhibitor, is present in the epithelial lining fluid and alveolar macrophages following intravenous dosing to healthy adult volunteers
Parul Patel, D. Tenero, G. Bowers, A. Patel, M. Kurtinecz, S. Croy, E. Dumont, J. Tomayko, S. Piscitelli, K. Rodvold, P. Patel* (King of Prussia, Research Triangle Park, Collegeville, Chicago, US)
01 April 2012 - P1420
A phase 1, open-label, multicentre, single-dose, pharmacokinetic, safety and tolerance study of oral tedizolid phosphate in 12 to 17 year old patients
Kelly Ann Munoz, J. Bradley, A. Arrieta, E. Capparelli, R. Jacobs, E. Fang*, K.A. Muñoz, S. Flanagan, P. Prokocimer (San Diego, Orange, Little Rock, US)
01 April 2012 - P1421
Phase I (multiple ascending dose) study with the novel Pseudomonas aeruginosa antibiotic POL7080 in healthy volunteers
Glenn E. Dale, K. Dembowsky*, D. Wilbraham, A. Ograbek, J. Argen, A. Wach, G.E. Dale (Allschwil, CH; London, UK)
01 April 2012 - P1422
Metabolic stability of PTK 0796 (omadacycline)
S. Tanaka, I. Hanna, H. Sun, B. Zhu, H. Gu, L. Wang, R. Pelis, E. Heidi, D. Chun, S.K. Tanaka* (East Hanover, Boston, US)
01 April 2012 - P1423
A single-dose study to evaluate the pharmacokinetics, safety, and tolerability of multiple formulations of PTK 0796 in healthy subjects
Michael Draper, H. Sun, L. Ting, R. Maietta, S. Machineni, J. Praestgaard, A. Kuemell, D. Stein, G. Sunkara, S. Kovacs, M. Draper* (East Hanover, Cambridge, US; Hyderabad, IN; Boston, US)
01 April 2012 - P1424
Lack of interaction of PTK 0796 (omadacycline) with human transporter proteins
S. Tanaka, I. Hanna, H. Sun, N. Alexander, A. Natrillo, R. Pelis, L. Wang, S.K. Tanaka* (East Hanover, Boston, US)
01 April 2012 - P1425
Mouse pharmacokinetics, dose fractionation and efficacy of TP-559, a novel tetracycline with anti-Pseudomonas activity, in murine infection models challenged with Pseudomonas aeruginosa
Joyce Sutcliffe, J. Sutcliffe*, X. Xiao, R. Clark, T. Grossman (Watertown, US)
01 April 2012 - P1426
The intravenous pharmacokinetics and efficacy of a novel tetracycline TP-433 in murine infection models challenged with Pseudomonas aeruginosa
Joyce Sutcliffe, Y. Deng, T. Grossman, R. Clark, X. Xiao, J. Sutcliffe* (Watertown, US)
01 April 2012 - P1427
TP-834, a novel IV and oral isoindoline-containing pentacycline, is highly efficacious in rodent models of pneumonia
Trudy Grossman, J. Sutcliffe*, P. Hogan, C. Katz, W. Zhang, Z. Zhu, T. Grossman (Watertown, US)
01 April 2012 - P1428
TP-834, an isoindoline-containing pentacycline antibiotic, is orally bioavailable, metabolically stable and has low potential for drug-drug interactions
Trudy Grossman, T. Grossman*, M. Ronn, N. Dunwoody, J. Sutcliffe (Watertown, US)
01 April 2012 - P1429
In vitro pharmacodynamics of AZD5206 against Staphylococcus aureus
Vincent Tam, V.H. Tam*, K.T. Chang, Z. Yang, J. Newman, M. Hu (Houston, Waltham, US)
01 April 2012 - P1430
[14C]-delafloxacin (RX-3341): distribution and elimination studies in the rat
Andrew McEwen, S. Runacres, L. Lawrence, M. Reeve, R. Hanselmann, D. Li, J. Longcor, A. McEwen*, C. Henson, S. Wood (Rushden, UK; New Haven, US)
01 April 2012 - P1431
Pharmacokinetics and safety of single and multiple doses of LFF571 in healthy subjects
Lillian Ting, C. Young*, L. Ting, P. Pertel, J.C. Yang, J. Praestgaard, N. Grunenberg, S. Komjathy, J. Leeds, M. Lamarche, M. Weaver (East Hanover, Cambridge, Tacoma, Emeryville, US)
01 April 2012 - P1433
Activity of XF-73 against methicillin-resistant and sensitive Staphylococcus epidermidis
Williams Rhys-Williams, S.A. Hassan, N. Ooi*, W. Rhys-Williams, W.G. Love, I. Chopra (Leeds, Brighton, UK)
01 April 2012 - P1434
XF-73, a novel porphyrin antimicrobial has antibacterial activity against Staphylococcus epidermidis irrespective of the growth state
Williams Rhys-Williams, S.A. Hassan, N. Ooi*, W. Rhys-Williams, W.G. Love, I. Chopra (Leeds, Brighton, UK)
01 April 2012 - P1432
Mechanism of action of XF-70, a novel porphyrin antimicrobial against Staphylococcus epidermidis
Williams Rhys-Williams, S.A. Hassan, N. Ooi*, W. Rhys-Williams, W.G. Love, I. Chopra (Leeds, Brighton, UK)
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