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ESCMID Global 2024
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From the archive: ECCMID and more before 2010
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17 April 2023 - P2222
Periplasmic target site penetration rates of four β-lactamase inhibitors in Klebsiella pneumoniae carbapenemase-2 (KPC-2)-producing Klebsiella pneumoniae
Yongzhen Zhang, Yinzhi Lang, Jieqiang Zhou, Xun Tao, Alaa R. M. Sayed, Eunjeong Shin, Carolin Werkman, Nicholas M Smith, Brian T. Tsuji, Jürgen B. Bulitta
17 April 2023 - P2182
Synergistic penicillin-binding protein (PBP) occupancy patterns in Klebsiella pneumoniae (KP) prospectively validated in a dynamic In vitro hollow fiber infection model
Eunjeong Shin, Alaa R. M. Sayed, Yinzhi Lang, Jieqiang Zhou, Jeremiah L. Oyer, Bartolome Moya, Abeer A.S. Elsayed, Dhruvitkumar S. Sutaria, Nirav R. Shah, Carolin Werkman, Rossie H. Jimenez-Nieves, Keisha C. Cadet, Xun Tao, Yuanyuan Jiao, Alicja J. Copik, Robert A. Bonomo, Herbert P. Schweizer, Richard E. Lee, John D. Boyce, Arnold Louie, Brian T. Tsuji, Afonso L. Barth, Alexandre P. Zavascki, George L. Drusano, Jürgen B. Bulitta
15 April 2023 - O0257
The AdeIJK efflux pump and AmpC β-lactamase predominantly contribute to the MICs of 42 BL and BLIs in wild-type Acinetobacter baumannii (AB) whereas the blaOXA-51-like β-lactamase and AdeABC pump do not
Keisha Cadet, Marianne Megroz, Rossie Jimenez-Nieves, Deanna Deveson Lucas, Amy Wright, Yongzhen Zhang, Yinzhi Lang, Bartolome Moya, Alaa R. M. Sayed, John D. Boyce, Jürgen B. Bulitta
15 April 2023 - E0109
Whole-cell penicillin-binding protein (PBP) binding of ceftazidime, avibactam, and aztreonam and elicited morphological changes in Klebsiella pneumoniae (KP)
Alaa R.M. Sayed, Abeer A.S. Elsayed, Bartolome Moya, Keisha Cadet, Rossie Jimenez-Nieves, Eunjeong Shin, Yinzhi Lang, Jieqiang Zhou, Yongzhen Zhang, Carolin Werkman, Brian T. Tsuji, Arnold Louie, George L. Drusano, Jürgen B. Bulitta
15 April 2023 - E0111
Synergistic killing of Acinetobacter baumannii (AB) elicited by simultaneous inactivation of three or all four penicillin-binding proteins (PBPs) among PBP1a, 1b, 2 and 3
Carolin Werkman, Nirav Shah, Marianne Megroz, Jeremiah Oyer, Deanna Deveson Lucas, Bartolome Moya Cañellas, Alaa Sayed, Abeer Elsayed, Amy Wright, Dhruvitkumar Sutaria, Xun Tao, Yinzhi Lang, Jieqiang Zhou, Eunjeong Shin, Cornelia Landersdorfer, Rossie Jimenez-Nieves, Keisha Cadet, Yuanyuan Jiao, Alicja Copik, Robert Bonomo, Arnold Louie, George Drusano, John Boyce, Jürgen Bulitta
25 April 2022 - O0634
Inhaled aztreonam and tobramycin dosing regimens against hypermutable cystic fibrosis Pseudomonas aeruginosa isolates in a dynamic in vitro biofilm model
Siobhonne Breen, Kate Rogers, Wee Leng Lee, Jessica Tait, Yinzhi Lang, Jieqiang Zhou, Juergen Bulitta, Roger Nation, Cornelia Landersdorfer
23 April 2022 - P2158
Combating SARS-CoV-2 by mechanistic insights from a highly sensitive intracellular UPLC-MS/MS assay for the parent and active triphosphate metabolite of EIDD-1931 (NHC) in infected ACE2-transfected A549 cells
Yinzhi Lang, Jieqiang Zhou, Evelyn J Franco, Kaley C Hanrahan, George L Drusano, Ashley N Brown, Jürgen B Bulitta
23 April 2022 - O0119
Time-course analysis of the metabolomic footprint of an MDR hypermutable Pseudomonas aeruginosa clinical isolate challenged with ceftolozane/tazobactam in a hollow-fibre infection model
Jessica Tait, Dovile Anderson, Kate Rogers, Yinzhi Lang, Wee Leng Lee, Jieqiang Zhou, Juergen Bulitta, Roger Nation, Darren Creek, Cornelia Landersdorfer
23 April 2022 - P1362
Ceftolozane/tazobactam in combination with tobramycin against the planktonic and biofilm states of hypermutable Pseudomonas aeruginosa isolates from paediatric patients with cystic fibrosis
Akosua Agyeman, Deanna Deveson Lucas, Carla López-Causapé, Kate Rogers, Eva Franklyn, Yinzhi Lang, Wee Leng Lee, Jieqiang Zhou, Jürgen Bulitta, Roger Nation, John Boyce, Antonio Oliver, Cornelia Landersdorfer
23 April 2022 - P1263
First whole-cell penicillin-binding protein (PBP) binding profiles of carbapenems and cefoxitin in Klebsiella pneumoniae (KP): characterising the mass balance of penetration and binding in periplasm
Alaa R.m. Sayed, Abeer A.s. Elsayed, Nirav R. Shah, Dhruvitkumar S. Sutaria, Bartolome Moya, Yinzhi Lang, Eunjeong Shin, Jieqiang Zhou, Carolin Werkman, Brian Tsuji, Arnold Louie, George L. Drusano, Jürgen B. Bulitta
23 April 2022 - P1262
Simultaneously inactivating three or all four penicillin-binding proteins (PBPs) among PBP1a, 1b, 2 and 3 synergistically kills Acinetobacter baumannii (AB)
Carolin Werkman, Nirav Shah, Deanna Deveson Lucas, Jeremiah Oyer, Marianne Megroz, Bartolome Moya, Alaa Sayed, Abeer Elsayed, Amy Wright, Dhruvitkumar Sutaria, Xun Tao, Yinzhi Lang, Jieqiang Zhou, Eunjeong Shin, Cornelia Landersdorfer, Rossie Jimenez-Nieves, Keisha Cadet, Yuanyuan Jiao, Alicja Copik, Robert Bonomo, Arnold Louie, George Drusano, John Boyce, Jürgen Bulitta
23 April 2022 - O0117
Synergistic penicillin-binding protein (PBP) occupancy patterns against Klebsiella pneumoniae (KP) characterised via confocal microscopy, flow cytometry, and quantitative systems pharmacology
Eunjeong Shin, Alaa R. M. Sayed, Yinzhi Lang, Jieqiang Zhou, Jeremiah L. Oyer, Bartolome Moya, Abeer A.s Elsayed, Dhruvitkumar S. Sutaria, Nirav R. Shah, Carolin Werkman, Rossie H. Jimenez-Nieves, Keisha C. Cadet, Xun Tao, Yuanyuan Jiao, Alicja J. Copik, Robert A. Bonomo, Herbert P. Schweizer, Richard E. Lee, John D. Boyce, Arnold Louie, Brian T. Tsuji, George L. Drusano, Jürgen B. Bulitta
15 April 2019 - P1834
Comprehensive thermal stability data and optimal supplement dosing schemes for in vitro time-kill experiments with 10 beta-lactams and 3 beta-lactamase inhibitor in Mueller-Hinton broth
Jürgen Bulitta, Yuli Qian, Xun Tao, Tae Hwan Kim, Jieqiang Zhou, Yinzhi Lang, Bartolome Moya, Dhruvitkumar Sutaria, Yuanyuan Jiao, Nirav Shah
15 April 2019 - P1833
Outer membrane permeability of 15 beta-lactams in multidrug-resistant Acinetobacter baumannii (MDR-AB) characterised via LC-MS/MS
Jürgen Bulitta, Xun Tao, Jieqiang Zhou, Yinzhi Lang, Bartolome Moya, Yuanyuan Jiao, Dhruvitkumar Sutaria, Nirav Shah, Tae Hwan Kim, Herbert Schweizer, Robert A. Bonomo, Richard E Lee, Arnold Louie, George Drusano, John Boyce, Deanna Deveson Lucas
15 April 2019 - P1832
First whole-cell assay to study the time-course of beta-lactams binding to penicillin binding proteins in Acinetobacter baumannii
Bartolome Moya, Dhruvitkumar Sutaria, Xun Tao, John Boyce, Deanna Deveson Lucas, Jieqiang Zhou, Yinzhi Lang, Yuanyuan Jiao, Nirav Shah, Tae Hwan Kim, Herbert Schweizer, Robert A. Bonomo, Richard E Lee, Arnold Louie, George Drusano, Jürgen Bulitta
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