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28 April 2024 - P2461
In vivo efficacy of humanized pulmonary exposures of WCK 5222 (cefepime/zidebactam) in neutropenic murine lung infection caused by carbapenemase-producing Klebsiella pneumoniae (KP) and Acinetobacter baumannii (AB) with WCK 5222
28 April 2024 - P2297
In vitro activity of cefepime/zidebactam (WCK 5222) against a panel of MDR/XDR Pseudomonas aeruginosa isolates from India enriched with resistance to novel β-lactam/ β-lactamase inhibitor combinations
28 April 2024 - P0793
Intensive care unit-onset bloodstream infections represent a distinct category of hospital-onset infections: a retrospective cohort study of bloodstream infections in ICU patients
17 April 2023 - P2190
Pharmacokinetics of BWC0977 in pulmonary epithelial lining fluid and efficacy in a neutropaenic lung infection model in rats
17 April 2023 - P2928
BKPy virus nephropathy and high level DNAemia in relation to ABO-incompatibility and genotype in kidney transplant recipients
16 April 2019 - O1063
WCK-771 (INN: levonadifloxacin): pharmacodynamic index (PDI) and PD target (PDT) determination studies involving methicillin /quinolone-resistant Staphylococcus aureus (MRSA/QRSA) employing neutropenic mouse lung infection model
16 April 2019 - P2769
Selection of EUCAST disk potency for WCK 4282 (cefepime-tazobactam, FEP-TAZ) susceptibility testing against Enterobacterales and Pseudomonas aeruginosa
16 April 2019 - P2770
Selection of EUCAST disk potency for WCK 5222 (cefepime-zidebactam, FEP-ZID) susceptibility testing against Enterobacterales, Pseudomonas aeruginosa and Acinetobacter baumannii
15 April 2019 - P2126
The neutropenic rat thigh infection model is ideal for characterisation of pharmacokinetics/pharmacodynamics (PK/PD) of antiinfectives following intravenous infusion administration
15 April 2019 - P1954
Population pharmacokinetics of zidebactam (WCK5107), a novel beta-lactam enhancer antibiotic, in individuals with various renal function
15 April 2019 - P1970
Population pharmacokinetics and dose adjustment of cefepime/tazobactam high dose (WCK4282) in patients with intermittent haemodialysis
15 April 2019 - P1941
Pharmacokinetic-pharmacodynamic (PK-PD) target attainment analyses to support WCK-771 (INN: levonadifloxacin) clinical dose selection
25 April 2017 - EP0943
Population pharmacokinetics, Monte Carlo simulations and dosing recommendations of cefepime using 2h infusion, including renal impairment
25 April 2017 - OS1017
WCK 4873 (Nafithromycin): PK/PD analysis for H. influenzae (HI) through murine lung infection model
25 April 2017 - OS1016
WCK 4282 [high-dose Cefepime (FEP)-Tazobactam (TAZ)]: In-vivo PK/PD studies identifying TAZ threshold concentrations (CT) against AmpC P. aeruginosa (PA)
24 April 2017 - P1350
WCK 4873 (Nafithromycin): Impact of hyper ermB induction in S. pneumoniae and S. aureus on the activity of ketolides
24 April 2017 - P1179
Population pharmacokinetics, Monte Carlo simulations and dose adjustment of tazobactam including in the renally impaired
24 April 2017 - P1302
A novel beta-lactam enhancer Gram-negative antibiotic, zidebactam (ZID) - phenotypic and genotypic characteristics of ZID-selected mutants of Enterobacteriaceae - expressing Class C, KPC and NDM
24 April 2017 - P1300
Zidebactam (WCK 5107) and WCK 5153: Bicyclo-acyl hydrazide penicillin-binding-protein (PBP) inhibitors showing potent beta-lactam enhancer activity against multidrug-resistant (MDR) metallo-beta-lactamase (MBL)-producing Klebsiella pneumoniae
24 April 2017 - OS0560
Unraveling the cefepime-zidebactam synergy basis against metallo-beta-lactamase (MBL)-producing Pseudomonas aeruginosa through penicillin-binding protein (PBP) binding dynamics
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