Cefepime/enmetazobactam is an innovative ?-lactam/?-lactam-derived ?-lactamase inhibitor combination with increased in vitro potency against KPC Ω-loop variants involved in ceftazidime/avibactam resistance
Impact of transferable β-lactamases and intrinsic AmpC amino acid substitutions on the activity of cefiderocol against wild-type and iron uptake deficient mutants of Pseudomonas aeruginosa
Antimicrobial susceptibility profiles, resistance genomics and activity of new ꞵ-lactam/ꞵ-lactamase inhibitor combinations against clinical Pseudomonas aeruginosa isolates showing treatment-emergent resistance to ceftolozane/tazobactam and ceftaz
Activity of cefiderocol and innovative β-lactam/β-lactamase inhibitor combinations against a Spanish nationwide collection of double carbapenemase-producing Enterobacterales
Antimicrobial activity of cefiderocol against the carbapenemase-producing Enterobacter cloacae complex and characterisation of reduced susceptibility associated with metallo-β-lactamase VIM-1
Assessing the impact of the most relevant chromosomally-encoded and horizontally-acquired Pseudomonas aeruginosa resistance mechanisms on resistance to cefiderocol, imipenem/relebactam, cefepime/taniborbactam, cefepime/zidebactam and aztreonam/av
Simultaneous and divergent evolution of resistance to cephalosporin/β-lactamase inhibitor combinations and imipenem/relebactam following ceftazidime/avibactam treatment of MDR Pseudomonas aeruginosa infections
Resistance prevention and resistance development dynamics to imipenem and imipenem/relebactam in carbapenem susceptible high-risk clones of Klebsiella pneumoniae KPC Ω-loop-mutants showing ceftazidime/avibactam-resistance
Resistance mechanisms to cefepime in the presence of novel ß-lactamase inhibitors zidebactam, taniborbactam and enmetazobactam in a Spanish nationwide collection of carbapenemase-producing Enterobacterales
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