TP-6076 is efficacious in a mouse pneumonia model with carbapenem-resistant Acinetobacter baumannii (CRAB) and retains potency against common tetracycline-resistance mechanisms
In vitro activity of eravacycline and comparators against Acinetobacter baumannii, including carbapenem-resistant strains, and Stenotrophomonas maltophilia isolated from patients in Europe
Eravacycline in vitro activity against clinical isolates obtained from urinary and gastro-intestinal sources, including drug-resistant pathogens, from patients in Europe
In vitro activity of eravacycline and comparators in Gram-negative organisms, including drug-resistant phenotypes, isolated from respiratory sources in Europe
In vitro activity of eravacycline and comparators against Enterobacteriaceae, including subgroups of strains with resistance to carbapenems or 3rd/4th-generation cephalosporins, isolated from patients in Europe
TP-076 is active in vitro against biofilms formed by a panel containing fluoroquinolone-resistant and susceptible uropathogenic Escherichia coli clinical isolates
Efficacy evaluation of TP-271, a novel fluorocycline, in a neutropenic murine pneumonia model against susceptible and resistant Gram-positive pathogens
Time to defervescence as an early marker of clinical response in patients with complicated intra-abdominal infections treated with eravacycline or ertapenem
Characterisation of baseline pathogens and microbiological eradication in a phase 2 trial for treatment of complicated intra-abdominal infections comparing eravacycline (TP-434) to ertapenem
Mouse pharmacokinetics, dose fractionation and efficacy of TP-559, a novel tetracycline with anti-Pseudomonas activity, in murine infection models challenged with Pseudomonas aeruginosa
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